Oxygen during inflammation helps E. coli thrive in an inflamed gut.

guthealth

The mechanisms driving gut bacterial imbalance.

During episodes of intestinal inflammation – which can occur during IBD and gastrointestinal infections and cancers – the composition of these gut microbial communities is radically disturbed.

“Beneficial bacteria begin to dwindle in numbers as less beneficial, or even harmful, bacteria flourish,” said Ms. Hughes. “This imbalance of microbiota is believed to exacerbate the inflammation.”

A healthy gut is devoid of oxygen. The beneficial bacteria that live there are well-adapted to the low-oxygen environment and break down fiber through fermentation. Unlike these beneficial bacteria, potentially harmful E. coli grow better in high-oxygen environments.

“Inflammation changes the environment so that it is no longer perfect for the commensal anaerobes, but perfect for opportunistic E. coli, which basically wait for an ‘accident’ like inflammation to happen,” Dr. Winter explained.

The increased availability of oxygen during inflammation helps E. coli thrive in an inflamed gut through a metabolic “trick,” Ms. Hughes said.

“Through respiration, the abundant waste products generated by the beneficial microbes can be ‘recycled’ by commensal E. coli – which do not grow well on fiber – and turned into valuable nutrients, thus fueling a potentially harmful bloom of the E. coli population,” she explained.

“If we interfere with the production of waste products by the beneficial commensal bacteria, then we impede their metabolism, which causes them to grow more slowly and throw off the entire ecosystem,” Dr. Winter said. “The most effective strategy may be to inhibit commensal E. coli‘s unique metabolism to avoid the bloom and negative impacts.”

Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis: Cell Host & Microbe

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s